抄録
With increasing survival after treatment for cancer, the incidence of second primaries has increased.Data from the Osaka Cancer Registry showed that the incidence rates of second primaries were associated with gender (male), age and calendar year at diagnosis of the first cancer. Patients who developecancer of the colon, larynx, lung, bladder or breast showed a significantly higher risk of developing second primary cancer than the expected, which was calculated based on the age, sex, and calendar-year specific incidence rates of cancer in Osaka. Laryngeal cancer patients showed a significantly increased risk for developing cancers of the mouth and pharynx, esophagus, liver, lung and bladder. Data from the Hospital Cancer Registry of the Osaka Medical Center for Cancer and Cardiovascular Diseases showed that patients diagnosed with cancer of the mouth or oro-, or hypo-pharynx had a significantly elevated risk for developing cancers of the mouth and pharynx, esophagus, larynx and lung. Such associations between first and second primary cancers seemed to be explained in large part by smoking and heavy drinking as shared risk factors. The effects of smoking and drinking on the risk for second primary cancers were also examined. It was suggested that smoking cessation might reduce the risk of second primaries among laryngeal cancer patients.
