A Novel Uncoupler of Mitochondrial Respiration, 9, 10-Epoxy-12-octadecenoate, Exists in Human Burned Skin

Kazuhisa YOKOO; Mika HAYAKAWA; Satoru SUGIYAMA; Takayuki OZAWA; Hisashi AOYAMA; Yohei IZAWA; Tadao KONDO; Yoshihiro HAYAKAWA

doi:10.3164/jcbn.1.121

Kazuhisa YOKOO, Mika HAYAKAWA, Satoru SUGIYAMA, Takayuki OZAWA, Hisashi AOYAMA, Yohei IZAWA, Tadao KONDO, Yoshihiro HAYAKAWA

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Keywords: epoxy-linoleate, burn toxin, mitochondrial respiration, uncoupler, human skin

JOURNAL FREE ACCESS

1986 Volume 1 Issue 2 Pages 121-127

DOI https://doi.org/10.3164/jcbn.1.121

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Abstract

In human burned skin, several polyunsaturated fatty acids, especially linoleate and its peroxide were isolated by high-performance liquid chromatography. Chemical structure of the epoxide was determined to be 9, 10-epoxy-12-octadecenoate by gas-chromatography/mass spectrometry, nuclear magnetic resonance measurements and ozonolysis. The epoxide showed an uncoupling activity to liver mitochondrial respiration and diminished the respiratory control of mitochondria. Formation of the epoxide in the burned skin was related to clinical observation of the “burn toxin” which appears after severe burns.

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