抄録
The effect of curcumin, which occurs in root of Curcuma Longa L., Zingiberaceae, on lipid peroxidation induced in rats by the administration of carbon tetrachloride or by 60Co-irradiation was examined. Administration of curcumin once a day for 3 successive days before the administration of carbon tetrachloride suppressed the increase in lipid peroxide level in the liver and that in activities of serum glutamate oxaloacetate and glutamate pyruvate transaminases in a manner dependent on the concentration of curcumin. Curcumin also prevented the morphological changes induced in the liver by carbon tetrachloride administration. When rats administered curcumin once a day for successive 5 days were irradiated with 60Co once a day for the last 3 days, the increase in serum and liver lipid peroxide levels was significantly suppressed.
