抄録
The effect of ellagic acid on lipid peroxide levels was examined in the placenta and fetus of pregnant rats irradiated with 60Co Upon whole body irradiation with 60Co (10Gy or 30Gy), the lipid peroxide levels in the placenta, in the liver and brain of the fetus, and in the serum, liver, spleen, and brain of the pregnant rat were significantly increased one day after the irradiation. When ellagic acid was administered either through a stomach tube or by intraperitoneal injection to the rat for 4 successive days before the irradiation, the increase in lipid peroxide levels in these samples, except for the brain of the pregnant rat, was significantly prevented. The effect on the placenta and fetus paralleled that found in the pregnant rat. By the administration of ellagic acid, the morphological changes such as degeneration of vascular endothelial cells of the placenta and liver cells of the fetus caused by the irradiation were prevented. The survival rate of the fetus after the irradiation was improved by ellagic acid. The effects of ellagic acid were approximately the same as those of α-tocopherol.
