Abstract
Echitamine chloride was tested for its anti-cancer effect on fibrosarcoma cells and far toxicity toward vero cells, a representative “normal” cell. In vitro incubation of these cells with different concentrations of echitamine chloride demonstrated the non-toxic nature of this drug on vero cells and its anti-cancer effect on sarcoma cells. The latter included reductions in cell viability, glutathione content, and [3H]-thymidine incorporation and increased lipid peroxidation. Interestingly, echitamine chloride caused 55% cell death at a concentration of 200μM in the case of sarcoma cells whereas vero cells were not affected even at the maximum concentration tested, i.e., 200μM.
