Status of Circulating Lipid Profile in Human Uterine Cervical Carcinoma before and after Therapy

Abstract

To study the status of circulating lipid components in human uterine cervical carcinoma, we collected blood from patients with different stages of uterine cervical carcinoma before and after treatment and also from a control population. Serum lipid was isolated; and the total lipid and their components such as total cholesterol, high-density lipoprotein (HDL)₂ cholesterol, HDL₃ cholesterol, phospholipids, triglycerides, free fatty acids, and lipid-bound sialic acid were determined. Some of the lipid components like phospholipids, triglycerides, free fatty acids, and lipid-bound sialic acid were found to be increased in advanced stages (stages III and IV) of carcinoma, when compared with the values for control subjects. Some of the altered lipid parameters were adjusted to near normal levels after radiotherapy and radiotherapy combined with chemotherapy. The increase in some of the lipid components might have been due to the elevated activities of lipolytic enzymes.