Abstract
Administration of pentazocine to adult male rats (3mg/kg body weight/day) for 10 or 20 days decreased their body weight significantly. The protein content of the serum also decreased significantly, whereas glucose level was elevated significantly only in the 20-day treatment group. Serum enzymes SGOT and SGPT exhibited increased activity after 10 or 20 days of administration of pentazocine, whereas the nonspecific serum esterases showed reduced activity. Further, the results showed the administration of pentazocine increased the serum total lipids, cholesterol, triglycerides, and phospholipids. The data suggest that the administration of pentazocine interferes with lipid metabolism and that it may alter metabolic function. Thus, the present study demonstrates that the administration of pentazocine modifies the biochemical contents and enzymes and thereby is likely to affect the structure and function of vital metabolic organs.
