Study of Dermal Wound Healing Activity of Trigonella foenum graceum Seeds in Rats
2000 年 28 巻 2 号 p. 59-67
詳細
2000 年 28 巻 2 号 p. 59-67
The influence of seed suspension of Trigonella foenum graceum (commonly known as fenugreek) was investigated for wound healing properties in excision, incision, and dead space wound models in rats. The seed suspension of T. foenum graceum 1ml/kg was given either topically or orally once a day. The granulation tissues formed were removed after 4, 8, 12, and 16 days of post excision wounding; and biochemical parameters such as DNA, total protein, total collagen, and hexosamine were estimated. The suspension increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increases in DNA, protein, and collagen contents of the granulation tissues. Quicker and better maturation and cross-linking of collagen was ob-served in the suspension-treated rats, as indicated by the high stability of acid soluble collagen and increase in aldehyde content and tensile strength. The orally treated wound was found to epithelize faster, and the rate of wound contraction was higher, as compared with the control wounds. The results show that T. foenum graceum produced different actions on the various phases of wound repair.
