Activation of Adrenergic β Receptor by Free FattyAcid Composition

Abstract

We report the novel molecular mechanism of activation of the adrenergic β receptor by free fatty acid composition based on the activated experimental structure of the receptor. Dimers of adrenergic β receptors have been stably formed due to sandwich structure between cholesterols and free fatty acids. Stabilization of the dimer formation enhanced signal communication initiated by the ligand binding.