Journal of Computer Chemistry, Japan
Online ISSN : 1347-3824
Print ISSN : 1347-1767
ISSN-L : 1347-1767

This article has now been updated. Please use the final version.

Activation of Adrenergic β Receptor by Free FattyAcid Composition
Yuka NAKANO, Saki KAWASE, Ayumi Sandou, Hiroaki TOKIWA
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Keywords: Keywords Adrenergic β receptor, Free fatty acid composition, Dimer formation
JOURNAL OPEN ACCESS Advance online publication

Article ID: 2011-0014

The final version of this article is now available: Vol. 11 (2012), No. 2 pp. 121-124
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Abstract
We report the novel molecular mechanism of activation of the adrenergic β receptor by free fatty acid composition based on the activated experimental structure of the receptor. Dimers of adrenergic β receptors have been stably formed due to sandwich structure between cholesterols and free fatty acids. Stabilization of the dimer formation enhanced signal communication initiated by the ligand binding.
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© 2012 Society of Computer Chemistry, Japan
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