電気泳動法と熱処理によるマクロポーラス水酸アパタイトセラミック膜の作製と評価

抄録

A macroporous hydroxyapatite ceramic coating was fabricated on a titanium substrate by an electrophoretic deposition (EPD) process followed by a heat treatment in order to obtain high performance bioactive porous hydroxyapatite. The key of this EPD process is a formation of composite particles by using a heterocoaguration reaction, consisting of hydroxyapatite ceramic nanoparticles for the ceramic frame material and monodisperse polystyrene polymer microspheres for template component, in a suspension. Microstructure of the porous ceramic coating layer depends on electrophoretic deposition parameters, and on heat treatment conditions. Under the optimized fabrication conditions, the hydroxyapatite ceramic coating layer with well-controlled macroporous structure was obtained. In vitro examination using a simulated body fluid revealed a good biocompatibility of the macroporous specimen.