日本結晶学会誌
Online ISSN : 1884-5576
Print ISSN : 0369-4585
ISSN-L : 0369-4585
4.生命科学分野におけるマルチプローブ研究
電子顕微鏡技術の進展と相関解析
岩崎 憲治
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ジャーナル フリー

2015 年 57 巻 1 号 p. 66-71

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Recent advances that improve direct electron detectors have revolutionized structural determination of biological molecules by cryo-electron microscopy. It has brought about the advent of near atomic resolution in single-particle reconstruction even with membrane proteins of 200~400 kDa. In fact, such high-resolution structures have allowed de novo building of atomic models. This rapid progress will change the quality and quantity of the conventional hybrid approach combining cryo-electron microscopy and X-ray crystallography or light microscopy, and computational methods such as molecular dynamics will also take on added significance to create integrated models of huge and complex macromolecules.

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© 2015 日本結晶学会
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