日本結晶学会誌
Online ISSN : 1884-5576
Print ISSN : 0369-4585
ミニ特集 核酸構造研究の新展開
アプタマー創薬と構造生物学
坂本 泰一
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ジャーナル フリー

60 巻 (2018) 2-3 号 p. 129-134

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Aptamers are nucleic acids that bind to a target molecule with high affinity and specificity, which are selected from systematic evolution of ligands by exponential enrichment (SELEX). Because of their high affinity and specificity, aptamers are strong candidates of next generation molecular targeted agents. However, for the development of aptamer therapeutics, chemical modification of aptamers is required to improve their nuclease resistance. For the efficient modification, structural information could be important. In this review, I describe structural biology of aptamers.

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