The application of high voltage transmission electron microscopy is the most effective approach to the high resolution observation of crystal and molecular structures at atomic level when based on the many beam principle for image formation. The results should be interpreted in terms of theoretical images computer-simulated on the basis of, for instance, multislice calculation procedure to avoid the misinterpretations of false images. Some electron photomicrographs are reproduced to show molecular and crystal structures of organic compounds such as chlorinated copper phthalocyanine, metal-TCNQ complexes and DNA. For some compounds, the images were obtained by the use of minimum dose system to reduce the influence of radiation damage which has a certain effect on the ultimate resolution. The intrinsic necessity of high instrumental resolution is also discussed in view of the feasibility to determine the structures as accurate as possible.
