Immunohistochemical Localization of Inhibin α-Subunit in Two Equine Granulosa-Theca Cell Tumors

抄録

Granulosa-theca cell tumor (GTCT) is the most common ovarian tumor in mares. Two adult Arabian mares presented with a history of persistent estrus (No. 1) and aggressive behavior (No. 2). Large unilateral polycystic ovarian masses were identified in each mare on rectal and ultrasound examinations. The masses were surgically removed and subjected to immunohistochemical staining. The histopathologic features of both ovarian masses were consistent with GTCT. Both tumors displayed positive immunoreactivity for inhibin α-subunit, but were negative for inhibin βA and βB subunits. This report indicates that appearance of inhibin α-subunit can be used as an immunohistochemical marker in the diagnosis of GTCT in equine.