Abstract
The influence of four types of fluorescence brightening agents (FBAs) on the yeast Saccharomycs cerevisiae in, as investigated. The FBAs used were derivatives of stilbene disulfonic acid disodium salt (FBA-1), coumarine (FBA-2), pyrazoline (FBA-3) and naphtylimide (FBA-4). FBA-1 inhibited the growth of yeast strongly, while FBA-2, -3 and -4 influenced the yeast only slightly. The growth inhibition of the yeast by each FBA can be correlated with the inhibition of sterol biosynthesis and with enzymes related to the electron-transport system in yeast. FBA-1 changed. the sterol composition by strongly accumulating the sterols found inthe early stages of biosyn- thesis and by strongly inhibiting the enzymes related to the electron-transport system. On the other hand, FBA-2, -3 and -4 did not have significant influence on either sterol biosynthesis or enzyme activity.
