Abstract
Objectives Drinking habits are closely associated with various lifestyle-related diseases. We investigated the effects of changes in alcohol consumption on lifestyle-related disease in subjects who underwent multiple health check-ups at the Tokai University Hospital Health Check-up Center.
Design Study of causation.
Methods The subjects were 19,382 repeated examinees who underwent multiple health check-ups at the Health Check-up Center in our hospital from 2005 to 2015. Using the questionnaire method, the drinking quantity was estimated, and the effect of the change on the parameter (body mass index (BMI), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FBG), uric acid (UA)) of the life-style related disease was analyzed, when the drinking quantity changed in first health check-ups and last health check-ups.
Results BMI, SBP, TG, FBG, and UA all worsened in a dose-dependent manner with increases in alcohol consumption, and improved when alcohol consumption decreased. HDL-C improved with increased alcohol consumption in a dose-dependent manner, and worsened with a decrease in alcohol consumption. The increase in alcohol consumption contributed to the development of metabolic syndrome, but it was through the deterioration of the parameters of lifestyle-related diseases and was not an independent factor.
Conclusion Increased alcohol consumption during the course of observation positively affected HDL-C but negatively affected all other lifestyle-related disease parameters.
