2022 Volume 49 Issue 4 Pages 457-461
Introduction: The incidence and mortality of colorectal cancer (CRC) has been increasing in Japan. Although the association between metabolic syndrome (MetS) and CRC has been previously reported, individual factors contributing to CRC occurrence are obscure, especially in Japan.
Aims & Methods: In this retrospective analysis of clinical data, we investigated metabolic and lifestyle-related risk factors for the occurrence of colorectal neoplasia (CRN) and advanced neoplasia (AN) using comprehensive health checkup data.
Demographic characteristics, anthropometric measurements, visceral fat area (VFA), hematological metabolic parameters, degree of fatty liver, and smoking/drinking habits were assessed in 2,769 subjects who underwent screening colonoscopy among 10,138 subjects who underwent comprehensive health checkups at our institute between August 2012 and December 2016. Associations between the variables and CRN or AN were evaluated by univariate and multivariate analysis.
Results: While 11.8% of subjects had CRN and 3.3% had AN, 24.4% of subjects were diagnosed with MetS. The presence of MetS was significantly associated with CRN and AN. Univariate analysis identified a significant association between CRN and age, sex, BMI, VFA, systolic and diastolic blood pressure (SBP/DBP), various hematological metabolic parameters, fatty liver, smoking/drinking habits, and weight gain. Multivariate analysis revealed that age, BMI, SBP, LDL, TG, and smoking/drinking habits were independent factors associated with CRN. Moreover, age, LDL, TG, and current smoking were recognized as independent factors associated with AN.
Conclusion: The present study demonstrated that metabolic factors, especially dyslipidemia, aging and current smoking, are risk factors for the development of colorectal neoplasia in Japan.
