Objectives: This study was designed to reveal the differences of the association of subjective sleep insufficiency (SSI) with aging-related atherosclerosis markers, in comparison among three age-groups (under 59, 60 to 69, over 70-years old) and between genders. It has been well-known that both aging and insomnia are associated with atherosclerosis. However, it is unclear how sleep might affect aging-related atherosclerotic status. It is necessary to look into an effective prophylaxis against atherosclerosis with due consideration of age and gender.

 Subjects: A total of 233 men and 248 women undergoing an anti-aging health checkup at Tokai University Tokyo Hospital were enrolled in the study.

 Methods: A statistical analysis was performed to assess correlation of age and atherosclerosis makers, and to investigate the impact levels of SSI on the aging-related atherosclerotic markers, in comparison among three age-groups in each gender.

 Results: We investigated that interleukin-6 (IL-6) in the over 70-years old men, insulin-like growth factor-1 (IGF-1) in the under 59 and the over 70-years old men were associated with SSI. Low-density lipoprotein cholesterol (LDL-C) of the 60 to 69-years old women was increased with SSI, after adjustment for some confounders.

 Conclusion: This study shows that our result may possibly show the pleiotropic function of IL-6 and IGF-1 among men. Furthermore, the insufficient sleep might increase the LDL level in women.

 Introduction: The incidence and mortality of colorectal cancer (CRC) has been increasing in Japan. Although the association between metabolic syndrome (MetS) and CRC has been previously reported, individual factors contributing to CRC occurrence are obscure, especially in Japan.

 Aims & Methods: In this retrospective analysis of clinical data, we investigated metabolic and lifestyle-related risk factors for the occurrence of colorectal neoplasia (CRN) and advanced neoplasia (AN) using comprehensive health checkup data.

 Demographic characteristics, anthropometric measurements, visceral fat area (VFA), hematological metabolic parameters, degree of fatty liver, and smoking/drinking habits were assessed in 2,769 subjects who underwent screening colonoscopy among 10,138 subjects who underwent comprehensive health checkups at our institute between August 2012 and December 2016. Associations between the variables and CRN or AN were evaluated by univariate and multivariate analysis.

 Results: While 11.8% of subjects had CRN and 3.3% had AN, 24.4% of subjects were diagnosed with MetS. The presence of MetS was significantly associated with CRN and AN. Univariate analysis identified a significant association between CRN and age, sex, BMI, VFA, systolic and diastolic blood pressure (SBP/DBP), various hematological metabolic parameters, fatty liver, smoking/drinking habits, and weight gain. Multivariate analysis revealed that age, BMI, SBP, LDL, TG, and smoking/drinking habits were independent factors associated with CRN. Moreover, age, LDL, TG, and current smoking were recognized as independent factors associated with AN.

 Conclusion: The present study demonstrated that metabolic factors, especially dyslipidemia, aging and current smoking, are risk factors for the development of colorectal neoplasia in Japan.

 Objective: We measured the antibody levels in our staff members over time after coronavirus disease 2019 (COVID-19) vaccination and examined changes in antibody levels after administration of the booster vaccination. We also examined the incidence of adverse reactions after three doses of the vaccine.

 Methods: The subjects were 137 employees of our corporation who received two doses of COVID-19 vaccine by Pfizer-BioNTech or Moderna between May and July 2021 and who were subsequently administered COVID-19 antibody testing over time. The antibody levels were measured by quantification of spike protein-specific IgG antibodies and were measured three times in total. The changes in the antibody levels were investigated in two groups who received an additional vaccine dose before the third antibody measurement or not. The incidence rates of adverse reactions were also evaluated.

 Results: In case who did not receive the additional vaccine dose, the mean antibody level decreased by 92% at 180 days after the first measurement was performed. On the other hand, in case who received the additional vaccine dose, the antibody level after the additional vaccine dose was 39-fold higher than that in those who were not vaccinated at the same time.

 Incidence of all adverse reactions was higher at the second and third measurements than at the first measurement.

 Conclusions: These results demonstrated that the antibody level declined considerably with time after vaccination. However, its levels increased sufficiently again after the additional doses. We emphasize that the additional vaccine doses are significant for preventing COVID-19 infection.

 The term "anti-aging" means an attempt to slow the process of the aging-induced decline of the physiological function leading to illness. Aging is inevitable, but pathological aging can be delayed by lifestyle modification and stress management. Interventional approaches are taken to reduce aging-related problems, such as dementia, locomotive syndrome, and frailty, even when the individual is in a healthy state before aging-related diseases appear. The goal of anti-aging medicine is the extension of the healthy life-span and realization of successful aging.

 The anti-aging health check-up system, also known as the anti-aging dock, can offer specialized examinations to detect early signs of age-related changes, such as vascular, hormonal, oxidative stress-induced, and body composition changes, and help people reduce age-related risks with specialists in anti-aging medicine. The items examined in the anti-aging dock of Tokai University Tokyo Hospital are divided into two major components: the "degree of aging" and "aging risk factors". Our anti-aging health check-up system provides not only various examinations, but also health guidance and nutritional advice, including dietary supplements the examinees personally need.

 Japan is already a super-aging society, and the proportion of elderly people is steadily increasing year by year. Thus, the need for primary prevention of age-related diseases through health screening is growing. This article provides a current overview of anti-aging medicine in Japan and experiences from the anti-aging health check-up system at Tokai University Tokyo Hospital, which can serve as a helpful perspective for health evaluation and promotion.

 The COVID-19 epidemic has caused a change in management of the disease undergoing medical treatment as well as numbers of participant of annual comprehensive health examination in Japan (Ningen Dock). We examined participants who attended to Health Evaluation and Promotion Center, Tokai University Hachioji Hospital during the fiscal year of 2019 and 2020. We selected the participants according to our original checklist whether they are low risk for current COVID-19 infection. We suspended the Ningen Dock during April 8th to June 7th, 2020, due to a declaration of a state of emergency by the Prime Minister of Japan. In 2020, 83.5% of participants in 2019 attended Ningen Dock. The numbers of participants who preferred an upper gastrointestinal (GI) endoscopy instead of an upper GI X-ray was 22.0% lower than that in 2019. The proportion of participants who visited our center for the first time decreased by 31.0% from 2019. The distributions of age and sex were not affected. The proportion of participants who were insured by municipalities and National Health Insurance Associations decreased by 28.9% and those who were insured by other insurers decreased by 14.4% from 2019. The decrement of participants who were not obligated to take an annual health examination was 23.2% from 2019. The decrement of participants who have no contract with our center was greater than those who have contract with the center (23.8% vs 14.2% from 2019). In conclusion, interventions are required to increase the participation rate for those insured by municipalities and National Health Insurance associations as well as those who were not obligated to take annual health checkups and those who have no contract with our center.