The effect of prenatal moderate aerobic exercise to inhibit the increase of oxidative stress

抄録

Background : Increase in oxidative stress during pregnancy may lead to deviation from normal pregnancy course. Performing aerobic exercise as a means to reduce oxidative stress during gestation period is an important lifestyle. We evaluated effects of aerobic exercise during gestation period since no study has investigated these using oxidative stress markers. Objectives : The present study aimed to examine the relationship between aerobic exercise and oxidative stress using physiological indices. Methods : 17 pregnant women in mid-pregnancy with no abnormalities in the pregnancy progress and no previous mental illness were recruited. Urine samples were collected before commencing aerobic exercise program during the second trimester and after completing 10 weeks of classes （three times per week） during the third trimester. Physiological effects of the exercise were determined by measuring urinary 8-hydroxy-2′-deoxyguanosine and 8-isoprostaglandin F2α levels. Results : Urinary 8-hydroxy-2′-deoxyguanosine level in the third trimester was significantly lower than that in the second trimester. The difference in this level tended to be lower for women who commenced classes at 6 months of pregnancy than for those who commenced at 7 months of pregnancy. However, no significant difference was observed in the correlation between the month of pregnancy and difference in 8-hydroxy-2′-deoxyguanosine level. No significant difference was observed in the correlation between the difference in urinary 8-hydroxy-2′-deoxyguanosine level and exercise intensity during classes. No significant difference in urinary 8-iso-prostaglandin F2α level was observed between the second and third trimesters. Conclusions : Performing moderate aerobic exercise three times a week from the second trimester of pregnancy reduced oxidative stress and suppressed 8-hydroxy-2′ -deoxyguanosine levels in vivo. In the future, we intend to test the association between aerobic exercise and par ticipant background in a larger population of primipara. Furthermore, comparison of 8-iso-prostaglandin F2α levels between control and experimental groups will be conducted.