2019 年 28 巻 4 号 p. 371-376
This study aims to evaluate the ability of poly(propylene carbonate) (PPC)-loaded nanohydroxyapatite (nHAp) membrane to regenerate bones. Methods: Six New Zealand white rabbits were randomly and equally divided into two groups. Four 6 mm diameter transosseous round defects were made at the parietal bone of each rabbit. One defect was not covered with the membrane, and the others were covered with 10% or 20% nHAp/PPC membrane or HEAL-ALL membrane. Animals of each group were sacrificed at the 4 and 12 weeks after the operation, respectively. The rabbit parietal bones were removed for radiological and histological evaluation. Results: Micro-computed tomography results showed that the bone regeneration of the experimental group was significantly higher than that of the control group in the absence of bone powder after 4 and 12 weeks, and the 20% nHAp/PPC group showed the most significant effect on bone regeneration. Histological analysis found that the nHAp/PPC membranes and HEAL-ALL membranes of the experimental groups prevent the growth of soft tissues during bone regeneration. In summary, the nHAp/PPC membrane showed good biocompatibility during the repair of rabbit parietal defects, and the 20% nHAp/PPC membrane is prominent.
