2022 年 31 巻 2 号 p. 127-132
To investigate the association of the interaction between peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) gene polymorphism and glycosylated hemoglobin (HbAlc) level with susceptibility to diabetic periodontitis (DP). A total of 259 DP patients and 257 patients with type 2 diabetes mellitus (T2DM) treated from August 2017 to April 2020 were enrolled, and another 180 healthy subjects were selected as control group. The HbA1c level of T2DM patients was determined using automatic biochemical analyzer. PPAR-γ2 gene Pro12Ala polymorphism was detected by the dideoxy chain termination method. The risk factors for DP were analyzed by multivariate logistic regression model. The adjusted odds ratio (OR) and 95% confidence interval of PPAR-γ2 gene Pro12Ala polymorphism and HbA1c level for the risk of DP were estimated, and the interaction between Pro12Ala polymorphism and HbA1c level was analyzed. The risk of DP increased in T2DM patients with genotypes Pro12Ala (PA) and Pro12Ala (AA) (OR=2.529, OR=2.594, P<0.01). T2DM patients with 6%≤ HbA1c <8% or HbA1c ≥8.0% had significantly elevated risk of DP (OR=2.046, OR=3.105), and T2DM patients with HbA1c ≥8.0% had higher risk of DP than those with 6%≤ HbA1c <8% (P<0.01). There was a positive interaction between HbA1c level and Pro12Ala (PA) and Pro12Ala (AA) (γ>1). Individuals with genotypes Pro12Ala (PA) or Pro12Ala (AA) are high risk population of DP. The interaction between these genotypes and HbA1c level facilitates the occurrence and development of DP. Measures should be taken to control HbA1c level or to regulate gene expression, so as to prevent DP.