上顎悪性腫瘍治療における5FU動注および照射の効果とその適量について
1973 年 19 巻 2 号 p. 121-126
詳細
1973 年 19 巻 2 号 p. 121-126
89 cases of maxillary cancer were treated in this clinic 1966 to 1971.32 cases of them were treated by combined therapy of surgery, irradiation and 5 FU intra-arterial infusion. Others of them were treated without chemotherapy by surgery and irradiation.
In this report the auther compared the result with chemotherapy and without chemotherapy. 5 FU increases irradiation effect which is very important in the treatment of maxillary cancer, so that 5 FU was adopted as chemotherapeutical agent. 250mg of 5 FU a day were infused almost by one shot.
Results were as follows:
1) 3 years survival rate was 48% with chemotherapy and 28% without chemothrapy.
2) Histological effects were seen distinctly in cases with 5 FU. There were a few cases in which living cancer cells were not seen. This fact indicated that radical operation is not always necessary in some cases with chemotherapy.
3) The most effective preoperative treatment for maxillary cancer was 3000 to 5000 mg 5 FU infusion with 3000 to 5000 rads irradiation.
4) There was no serious secondary effect except one facial nerve palsy in this combined therapy.
