メニエール病に対するCinnarizine (Roin) の治療効果

抄録

The present study was undertaken to investigate Cinnarizine for its effectiveness in the treatment of Ménière's disease. A total of 41 newly admitted or readmitted patients with Meniere's disease were involved in this study. Of these 41, 5 were in the attack stage, 27 were in the quasi-attack stage (less than 1 month after attack) and the remaining 9 were in the silent stage between attacks. In 4 of the first 5 cases the use of Cinnarizine resulted in a prompt disappearance or reduction of vertigo, tinnitus and nystagmus,(adrenocortical hormone not used because of side effect). In 25 of the 27 cases in the quasi-attack stage the use of Cinnarizine brought about suppression of vertigo and tinnitus with a subjective improvement in general condition. Two of the 9 cases in the silent stage between attacks had recurrence of attack under therapy with the drug. On an overall basis symptomatic improvement rate was estimated to be 72% for vertigo, 78% for tinnitus, 50% for nystagmus, 40% for deviation on stepping tests and 33% for hearing impairment. From these results it seems justifiable to assume that Cinnarizine is effective in the relief of symptoms of Meniere's disease during its attack and quasi-attack stage.