中耳粘膜におよぼすEmpecidの安全性の評価

走査型電顕による観察

抄録

The present SEM observation was performed for clarifing the evaluation and the influence of 0.25% Empecid (clotrimazole solution) and polyethlene glycol, as using as the otic solution, to the cilia of the middle ear mucoepithelium in normal guinea pig.
On 7th day, after receiving of these solution, cilia of the both group animals showed marked degeneration, which were the disappearance and confusion of cilia, and the appearance of secreted amorphous substances. On 14th day, these degenerated cilia had started to regenerating and had showed the new normal cilia on the final 21st day.
The result of this experiment suggested that the degenerated cilia cells due to 0.25% Empecid might be able to regenerate, with in 2 weeks.