抄録
The nasal polyp and antrochoanal polyp were by product of a chronic inflammation in the paranasal cavity. They were formed on the association with the paranasal mucous membrane. So that, it was an important factor forming them that the paranasal mucous membrane pathologically proliferated and invaded into the nasal cavity. On the other hand, it was established that in tissue culture using the human embryonic kidney cell and the transformed cell, the growth and production of their cells were closely related to the activity of protease and antiprotease in them.
We suggested that the enlargement of nasal polyp might be subjected to a protease-antiprotease system in this tissue. At first, in order to clarify the relationship of nasal polyp and the activity of protease-antiprotease, we observed the activity of their enzymes in tissue extract of an antrochoanal polyp.
The results obtained from this experiment were as follows:
1. It was observed in tissue extract that the activity of plasminogen tissue activator was scanty but the activity of SK-proactivator was remarkable.
2. This SK-proactivator was stable at acid and neutral pH, but was labile at alkaline pH in thermostability.
3. The inhibitory activity to some proteases, so that, trypsin and papain was not observed. From these results, it became appeared that the fibrinolytic enzyme, especially a SK-proactivator was a dominant enzyme in a protease-antiprotease system of the antrochoanal polyp tissue. Furthermore, this paper was described about the property of the proactivator in blood and body fluid in comparison with it in the antrochoanal polyp. Until the present time the existence of a SK-proactivator has not been reported in body tissue, although it has been known in human blood and body fluid. This is the first report to deal with SK-proactivator in the tissue.
