Concentrations of cefsulodin in the mucous membrane of middle ear and otorrhea were studied. Sixteen patients who underwent tympanoplasty or radical mastoidectomy were intravenously injected with a 1g dosage of cefsulodin before the operation. Mean cefsulodin concentration in the mucous membrane were 29.0, 30.4 and 16.3 μg/g at 0.5, 1 and 2 hours after injection, respectively. Five patients with chronic suppurative otitis media were intravenously injected with a 1g dosage of cefsulodin. Otorrhea was collected using 6mm paper discs and cefsulodin concentrations in the samples were determined. Concentrations in otorrhea were 9.5 μg/g at 2 hours after injection. The tissue concentrations exceeded the antibacterial levels of cefsulodin against Pseudomonas aeruginosa.
