耳鼻と臨床
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
鼻アレルギーの治療
発症のメカニズムから
奥田 稔
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ジャーナル フリー

1984 年 30 巻 4Supplement2 号 p. 742-747

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The nasal manifestation of allergy on the muscosal surface is triggered by a number of mechanisms in different steps Therefore, the treatment should be understood on the basis of knowledge of the following steps; elution of antigenic substance from antigenic particles is inhibited by decreased hypersecretion (cholinergicblockade); interaction of antigenic substance with the surface basophilic cells is suppressed by decreased migration of these cells to the mucosal surface (topical steroid or immunotherapy) and is slightly affected by increased blocking antibody in the mucous layer (immunotherapy); mediator release from the surface basophilic cells is inhibited by a changed enzymic process or by a decrease in the production of the mediator in the cells (mast cell stabilizing agents, immunotherapy); allergic nasal tissue reaction may be suppressed slightly by quick binding of released histamine with protein (histamine-gammaglobulim compound) or is done by decreased nasal sensitivity to histamine (H1 blockad, sedative, Asthremedine, α-stimulant, and cholinergic blockade).

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