追跡法に依る聴器迷路アレルギーの実験的研究

抄録

Allergic reaction (Antigen-Antibody reaction) was observed in the ear labyrinth of rabbits, provocating Artus or Schwartzmann's phenomenon. As the tracer, Metal zine was combined to the both antigens with the care being taken not to disturb the activity of the antigens. Zinc tracer was detected as fine orange granules in the labyrinth tissue after the experiment by histochemical method. (E. Eegriwe) And these orange granules indicated the degree and, the site of the reaction.
The results obtained were as follows:
1) The clinical findings: Spontaneus nystagmus appeared in one third of the rabbits immediately after the injection. Postrotatory nystagmus decreased about in half of the cases. Positional nystagmus appeared in halft of eh cases rapidly, however in general, disappeared within a moment. Oto-lith reflex generally decreased after the injection.
2) The histopathological findings : Edematous swellung and dilatation of blood vessels in the laby-rinth tissue were seen in a short time after the injection. Orange granules scattered especially alcng the wall of fine blood vessels. Allergic reaction occurred more rapidly and more severely on Vasc-ular stria and around the Saccus endolymphaticus, suggested by the mass of zinc granules. In Cortis organ, the tracer were deposited Deiter's Hensen's and Claudius's cells, a part of the support cell groups, however sensory epitherium did not show anyreaction. Sensory endorgans in Vestibular labyrinth showed generally the same changes as in the Cortis organ.