鼓室内薬剤注入と迷路通電刺激による迷路性筋反応

抄録

An experiment was performed on the effects of drugs on the labyrinthine muscular response in the bilateral deep nape muscles (M.rectus capitis posterior major et minor) of rabbit. These drugs such as antihistamin (i.e.of aminoether, phenothiazine), local anesthetica (i.e. cocaine, alcohol), sympathomimetic drugs (i.e.adrenalin, atropine.and pilocarpine), and interneuro. anal blocking agent (i.e.meprobamete), were infused into the tympanic cavity of normal and decerebrated rabbits, and anodal and cathodal galvanic stimulation was given to the animals upon the labyrinth (Nippon Koden MSE 2 Type stimulator),
I measured voltage and amperage of the cathodal galvanic stimulation, when labyrinthine muscular response occured in the contralateral deep nape muscles for the purpose of determining the threshold of the stimulation.
The obtained results are as follows:
1.Both decerebrated and non-decerebrated rabbits showed labyrinthine muscule response even after drug-infusion as well as before.
2.In the non-decerebrated rabbits, the threshold in the labyrinthine muscular reaction decr-eased after the infusion of pilocarpine or alcohol (in exciting stadium of alcohol).
3.In the non-cerebrated rabbits the threshold increased after the infusion of restamia, cocaine, alcohol (in anesthetic stadium), adrenalin, contomin, and atropine.But it did not change after infusion of meprobamate.
4.The decerebrated rabbits showed pronounced reactions than the normal after drug infusion, and the threshold in the decerebrated was lower than in the non-decerebrated.