andida albicansによる口腔咽頭潰瘍の実験的研究特に組織学的特徴に就ての対照実験

抄録

We had reported the histological findings of experimental candida albicans ulcer in a preceding article, in which we reported that the infiltrating cells were predominantly histiocytes and the proliferation of the young granulation tine was significant.
The most characteristic finding was the proliferation of the capillary blood vessels, resembling to hemangioma. In the late stage of the ulcer the giant cells were demonstrated. These histological findinding is similar to that of the oral candida ulcer of the human. To confirm these histological characteristics of candida infection, the author has studied the ulcers due to morbid candida albicans and staphylococci.
The ulcers due to morbid candida albicans were produced in 9 of 12 experimental animals, they were small and superficial, and these ulcers healed spontaneously in 11 to 13 days in average.
The histological findings in its peak stage were less significant than that of ulcer due to living candida albicans, the histiocyte infiltration was less, the capillar prolification was less remarkable and the giant cells were not identified.
The ulcers due to staphylococci were demonstrated in 3 out of 10cases. In 7 cases the abscess was formed but resolved without ulcer formation. Concerning histological appearance, the ulcer had a superficial and irregular shape and the margin of the ulcer was not undermined, histologicaly the infiltration of the polymorphneuclear cells were markedly demonstrated, but the edema in the tissue and the capillary proliferation were less remarkable. The giand cells were not found.
Based on the above-mentioned experimental study of the oral ulcer due to morbid candida albicans and staphylococci, the author has concluded that the histological findings which we have found in the candida albicans ulcer must be specific to oral candidiasis.