上顎癌3者併用療法とくに放射線抵抗性腫瘍の治療について

抄録

Clinical observations were made on 14 patients with maxillary tumors resistant to radio-therapy. A combined therapy consisted of partial resection of the maxillary tumor, radio-therapy with small dosage, and local chemotherapy was applied to them. The aim of the combined therapy is to allow patients to keep a social as well as professional life with minimal facial deformity.
The age of 14 patients ranged from 17 to 82 years old. Histopathology of the patients included 4 malignant melanomas, 3 fibrosarcomas, 2 neurofibromsarcomas, 1 leiomyosarcoma, 1 chondrosarcoma, I osteosarcoma, 1 olfactory neuroblastoma and 1 meningioma.
A radiation dosage of approximately 1, 400 rad was given in 7 sessions before and after partial tumor resection. The patient was examined twice a week and the remnant of the tumor was debrided locally in outpatient clinic. After the wound healing was achieved, the patient was under observation in the outpatient clinic for many years. As soon as recurrence was detected, treatment was per formed as aforementioned way.
Using the combined therapy, the patients could retain the structure and function of theregion, and a rehabilitation was greatly simplified.