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81 巻, 3 号
選択された号の論文の8件中1～8を表示しています
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村上 泰, 向井 将, 大築 淳一, 佐藤 学, 猪狩 武詔, 岡本 亮二, 原口 茂徳1978 年 81 巻 3 号 p. 195-203
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーLocal recurrence after partial laryngectomy is usually controled by total laryngectomy. Recurrence in the neck as a metastasis to the cervical lymph node is also to be salvaged by neck dissection. Besides these common types of local recurrence, there are some annoying cases such as;
1, recurrence in the hypopharyngeal cavity after total laryngectomy,
2. recurrence which is close to and invades into the hypopharyngeal wall after total laryn-gectomy,
3. recurrence combined with severe necrosis including the skin after total laryngectomy,
4. stomal recurrence,
5. stenosis in the subglottis and in the cervical trachea after hemilaryngectomy due to recur-rence mostly in the thyroid gland or in paratracheal lymph nodes,
6. recurrence in the base of the tongue after total or supraglottic laryngectomy, and
7. recurrence in the parotid region after neck dissection.
For the treatment of these troublesome recurrences, radiation combined with chemotherapy is not indicated, since tissues containing tumor cells are cicatrically anoxic and do not respond well. Wide field resection and primary reconstruction of the defect should be advisable in as early stage as possible. Careful consideration to the possibility of complete resection, however, should be given in every case before decision of definitive surgery. Detailed examinations to qualify whether the tumor spreads into the mediastinum, prevertebral soft tissues or the oropharynx are essential for identifying the limit of surgical procedure. Some clinical problems are shown and discussed with several case reports.抄録全体を表示PDF形式でダウンロード (5023K) -
第1報 ヒト急性扁桃炎の血中線溶に関する研究小杉 忠誠, 浜谷 松夫1978 年 81 巻 3 号 p. 204-213
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーIt has been shown that biological activities of protease and antiprotease have modified a various phase of some inflammations. In order to clarify the relationship between these enzymes and the process in tonsillitis, we accomplished a series of studies on the circulating blood and tonsillar tissues with tonsillitis from the aspect of prote ase-antiprote ase activity. At first, fibrinolytic activity in the blood with acute tonsillitis was observed, since various methods of measuring fibrinolytic activity have been recently developed. Affinity chromatography has been applied for estimating fibrinolytic activity, then we could measure accurately this enzyme activity in the blood. Furthermore, it became possible to determine fibrinogen or fibrin degradated products (FgDP or FDP) in the circulating blood. Prior to determination of fibrinolytic activity in the blood with acute tonsillitis, chemical properties and biological activi-ties of FgDP were studied in vitro. The method of producing FgDP in vitro was as follows. Urokinase solution was added to fibrinogen (bovine) solution rich in plasminogen, and then this mixture was incubated at 37-C for various minutes. From this fundamental experiment on FgDP, it was shown that clotting activity to thrombin was inhibited by early digested products (FgDP). On the observation of fibrinolytic activity in the blood with acute tonsillitis, fibrinogen was determined by the modified Quick's method. After plasminogen was separated from the plasma using affinity chromatography, it was activated to plasmin by streptokinase (SK). Plasmin (SK-activated) activity was determined by the plasminogen free fibrin plate(commercial). The level of FgDP or FDP was measured using the latex-aggregation method. In comparison with normal adults, fibrinogen content was significantly increased in the blood of patients with acute tonsillitis (p<0.001). Plasminogen content was significantly decreased (p<0.005) and the level of FgDP or FDP was significantly increased (p<0.01). From these results obtained, it is evident that fibrinolytic activity in the blood of the patients with acute tonsillitis is increased. Protease-antiprotease抄録全体を表示PDF形式でダウンロード (1158K) -
高橋 由美子1978 年 81 巻 3 号 p. 214-223
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーClinical observations were made on 14 patients with maxillary tumors resistant to radio-therapy. A combined therapy consisted of partial resection of the maxillary tumor, radio-therapy with small dosage, and local chemotherapy was applied to them. The aim of the combined therapy is to allow patients to keep a social as well as professional life with minimal facial deformity.
The age of 14 patients ranged from 17 to 82 years old. Histopathology of the patients included 4 malignant melanomas, 3 fibrosarcomas, 2 neurofibromsarcomas, 1 leiomyosarcoma, 1 chondrosarcoma, I osteosarcoma, 1 olfactory neuroblastoma and 1 meningioma.
A radiation dosage of approximately 1, 400 rad was given in 7 sessions before and after partial tumor resection. The patient was examined twice a week and the remnant of the tumor was debrided locally in outpatient clinic. After the wound healing was achieved, the patient was under observation in the outpatient clinic for many years. As soon as recurrence was detected, treatment was per formed as aforementioned way.
Using the combined therapy, the patients could retain the structure and function of theregion, and a rehabilitation was greatly simplified.抄録全体を表示PDF形式でダウンロード (1666K) -
津田 祥明1978 年 81 巻 3 号 p. 224-232
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーThe aim of the present study was to investigate the mechanism of central frequency dis-crimination of a single formant. In the first part of the experiment, difference limen of central frequency (FDL) was measured using various types of complex sounds which were obtaine from white noise or pulse tones through a single formant circuit (an active filter). In the second part, the effect of the change in the band width of the circuit was examined.
As a result, it was found that FDL was better for the sounds obtained from pulse tones of low frequency than for those from high frequency pulse or white noise. The effect of the change in the band width of the circuit was found to be unremarkable and there was a con-siderable individual variation. It was assumed from the present study that the function of so-called critical band played an important role in perception of acoustic characteristics within the range near the central frequency of a single formant. A supplemental role of information from the marginal portion of the basal membrane of of the cochlea was discussed.抄録全体を表示PDF形式でダウンロード (2007K) -
宮原 裕, 松岡 寿子, 東家 倫夫, 大渕 正博, 佐藤 武男, 前田 和雄1978 年 81 巻 3 号 p. 233-241
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーA total of 54 cases of radiation cancers in the head and neck region were treated and analysed.
The results were as follows;
1) Primary diseases irradiated previously were benign diseases of 37 cases, which included 29 cases of tuberculous cervical lymphadenitis and 3 of dermal disease, and malignant neoplasm of 14 cases containing 9 of laryngeal cancer and 2 of thyroid cancer.
2) Radiation cancers were divided to 23 hypopharyngeal, 14 thyroid, 10 cervical esophageal and other cancers.
3) Interval between irradiation and development of cancer showed that patient irradiated for malignant conditions had shorter intervals, with an average of 9.4 years, as compared with patients for benign conditions with an average of 33 years.
4) In regard to pathological findings, 59 were well differentiated squamous cell carcinomas in the pharynx, larynx, etc, and 14 were papillary and follicular adenocarcinomas in the thyroid gland and a case of fibrosarcoma of the upper lip.
5) Most cases were operated.
6) Prognostic consideration showed bad course and especially prognosis was miserable in cases of field cancerization.
7) Recently cancers after irradiation for malignant neoplasms were increasing.抄録全体を表示PDF形式でダウンロード (2816K) -
平杉 嘉昭1978 年 81 巻 3 号 p. 242-263
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーA basic study of electrocochleography (ECoG) was performed on guinea pigs with kana- mycin (KM) intoxication, using the same apparatus and method as for humans. Histrogical observation of the hair cells was carried out under a light microscope after succinic dehydro- genase (SDH) staining and surface preparation. The relationship between the cochlear poten- tials (AP, CM and SP) and the degree of hair cell damages was examined.
The following results were obtained:
1. The elevation of the threshold of AP response to a click was correlative with the degree of hair cell damages, especially in the cases of the outer hair cell damages on the lower turn. The of elevation the AP threshold was found to be 40 dB SPL (sound pressure level) in these cases.
2. The amplitude of AP response to a click was correlative with the degree of hair cell damages. In the cases of the outer hair cell damages on the lower turn, the AP amplitude decreased.
3. The latency of AP response to a click showed a tendency to prolong in the cases ofthe outer hair cell damages on the lower turn.
4. The elevation of the threshold of CM response to a pure tone burst was correlative with the degree of outer hair cell damages, starting from the high frequency range.
5. The decrease in amplitude of CM response to a pure tone burst was correlat*ve with the degree of outer hair cell damages on the lower turn. The CM amplitude decreased sepeci-ally in the cases of the outer hair cell damages on the lower turn.
6. For the component of SP, the baseline shift was recorded in ECoG. A large negative SP was recorded in the cases of the outer hair cell damages on the lower turn.抄録全体を表示PDF形式でダウンロード (1830K) -
小林 武夫, 寿尾 彬, 新美 成二, 滋賀 秀壮, 高橋 文夫1978 年 81 巻 3 号 p. 264-269
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーIn order to investigate the influence of photochemical smog upon the upper respiratory systems of humans, long-term examinations were made on junior high school students in urban districts. Objective methods were devised for better description of the color of the mucosa as well as for evaluating olfactory functions. Examinations were made on the day of photochemi- cal smog and the results were compared with those obtained before and after the smog season. The results were as follows;
1) On inspection of the nose and throat, no specific findings were noticed on the day of photo- chemical smog.
2) Color analysis of the nasal mucosa on the day of photochemical smog showed that there was a tendency toward decrease in "chroma".
3) No abnormalities were found in olfactory function on the day of photochemical smog.抄録全体を表示PDF形式でダウンロード (312K) -
時田 喬1978 年 81 巻 3 号 p. 297-300
発行日: 1978/03/20
公開日: 2008/03/19
ジャーナル フリーPDF形式でダウンロード (658K)
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