リンゴ花粉症における血清学的研究

特にRadioallergosorbent test (RAST)による特異的IgE抗体の検討

抄録

To investigate the immunological aspect of subjects sensitized by apple pollen, the "radioallergosorbent test" (RAST) by the modified paper disc method was performed for 28 patients with apple pollinosis and 15 control other nasal allergic patients. These results lead to the following conclusion:
1) The presence of specitic IgE antibody against apple pollen antigen was proved in sera of patients with apple pollinosis.
2) Mean RAST score and % count were 1.511±0.915; 5.76±0.61%, and percentage of positive RAST was 49.51±7.56%. These values were relatively low in spite of the patient's severe nasal symptoms, and were lower than those of the other pollinosis.
3) The difference between RAST score in the episodic stage and that of the nonepisodic stage was not noticed. Therefore, RAST against apple tree pollen antigen is considered to be diagnostically valuable throughout the year.
4) The percentage of positive RAST corresponded with those of the skin test and the nasal provocation test. So, RAST seems to be sufficient for diagnosing apple tree pollinosis.
5) The cross-allergenicity was observed in not only each sorts of apple pollen but also in other pollen belonging to the same "rose" family, such as a pear, peach, cherry and plum pollen, except for rose pollen.