Majority of patients with abnormal sensation in the throat (AST) are in the 3rd, 4th and 5th decades of life and those under 20 years of age are believed to be very rare. It, however, should be explored whether the incidence of AST in young generation is undoubtedly rare or not. The present statistical survey was conducted on 6162 primary, junior high and high school pupils to investigate the incidence of AST in children and young adults. Of the 6162 pupils, 1570 (25.5%) had AST which included irritating itchy (16.4%), a lump (12.5%), a paste (5.5%) and/or choking (1.9%) sensation. The pupils with AST had repeatedly recurring sore throat, stiff shoulders and sleeplessness with a significantly higher incidence than those without AST. Such symptoms as AST, stiff shoulders and sleeplessness were thought to be caused by inflammatory changes in the throat. It can be concluded that children and young adults with AST are not rare but few of them seek medical aid.
To investigate the immunological aspect of subjects sensitized by apple pollen, the "radioallergosorbent test" (RAST) by the modified paper disc method was performed for 28 patients with apple pollinosis and 15 control other nasal allergic patients. These results lead to the following conclusion: 1) The presence of specitic IgE antibody against apple pollen antigen was proved in sera of patients with apple pollinosis. 2) Mean RAST score and % count were 1.511±0.915; 5.76±0.61%, and percentage of positive RAST was 49.51±7.56%. These values were relatively low in spite of the patient's severe nasal symptoms, and were lower than those of the other pollinosis. 3) The difference between RAST score in the episodic stage and that of the nonepisodic stage was not noticed. Therefore, RAST against apple tree pollen antigen is considered to be diagnostically valuable throughout the year. 4) The percentage of positive RAST corresponded with those of the skin test and the nasal provocation test. So, RAST seems to be sufficient for diagnosing apple tree pollinosis. 5) The cross-allergenicity was observed in not only each sorts of apple pollen but also in other pollen belonging to the same "rose" family, such as a pear, peach, cherry and plum pollen, except for rose pollen.
In order to investigate the influence of the labyrinthine status on body sway, 60 normal persons and 73 patients with unilateral peripheral vestibular disorder were examined by stabilometry. Results were analyzed, by signal processor 7T17 (NEC, SANEI), with respect to three basic components: extent, speed and direction of body sway. The affected side of the patient was decided by neurotological examinations and the status of the diseased labyrinth was diagnosed as "irritative or paralytic", by the direction of spontaneous nystagmus. From this investigation, the following results were obtained: 1) The extent of body sway in patients with spontaneous nystagmus was greater than normal, and the speed of body sway towards the direction of spontaneous nystagmus was faster than that in the opposite direction. 2) A characteristic difference in body sway between the patients showing irritative nystagmus and the patients showing paralytic nystagmus was observed in the direction component. In the irritative labyrinthine stage, divergence of body sway was observed and patients fluctuated to all directions. In contrast, patients in the paralytic labyrinthine stage fluctuated to the right and left sides, thus the characteristic sway in this stage was lateral. 3) Patients without spontaneous nystagmus, in spite of showing "labyrinthine preponderance" by Contraves computerized rotary chair system, did not sway beyond the normal range. This discrepancy was thought to be caused by neurophysiological differences between the vestibuloocular reflex and the vestibulo-spinal reflex.
To know the influence of"high-potassium" of the perilymph on the labyrinthine and sensory cells function, the K+ -iontophoresis was performed for the right ear of 52 guinea pigs. In this experiment, the following results were obtained: 1) ENG study revealed at first irritative nystagmus, directed to the iontophoretic side, which was soon switched over paralytic nystagmus, directed to the unaffected side. This "2 phasic change of vestibular function" was proved by the measurement of succinate dehydrogenase-activity in the vestibular sensory cells. But, there was some delay between the reversal of nystagmusdirection and the change of enzyme activity. This delay suggested the influence of central efferent system. 2) There was no particular morphological change of the sensory cells of crista ampullaris in both irritative and paralytic stage (TEM). 3) ECoG study revealed the decrease of the action potential from the beginning, and the enzyme activity of the cochlear sensory cells was impaired without any irritative sign.