Of 27 patients with unilateral paranasal sinus disease detected by CT scans, 15 had tumors and 12 had inflammatory disease or cysts. Most of those with malignant tumors had CT evidence of bone destruction. Maxillary sinus wall thickening was usually found in patients with inflammatory disease or cysts. However, two patients with malignant tumors showed only bone thickening. Therefore, pathological examination by biopsy or exploratory opening of the sinus should be performed when unilateral paranasal sinus disease is found.