抄録
A 49-year-old woman complained of oral pain and a sore throat. Multiple erosive lesions with a white coated mass were found on her buccal mucosa and tongue. Short-lived bullae, which quickly ruptured, were also prominent on these lesions. The Nikolsky sign was demonstrable in uninvolved mucosa. A lip biopsy specimen showed an intraepidermal blister at the suprabasal cell layer with acantholysis and an intercellular deposition of type 3 complement. There was no involvement at other mucosal or skin sites. These findings were consistent with pemphigus vulgaris. Oral administration of prednisolone and cyclophosphamide was given initially, but the response was transient. Thus, she was treated with pulse intravenous methylprednisolone. Symptoms and pharyngeal lesions notably improved as a result of the treatment. Therapy with 10mg/day of prednisolone and 42mg/day of cyclophosphamide has been maintained and the patient has not experienced a relapse.
