抄録
This study investigated the effects of the simultaneous administration of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and taurine (Tau) on the blood pressure, serum lipids, free amino acid and fatty acids of the brain of SHR (spontaneously hypertensive rats) fed hypercholesterolemic diets.
In addition, we examined the relationship between the angiotensin- I converting enzyme (ACE) activity and the blood pressure by the simultaneous administration of these components and peptide from the muscle of Pacific mackerel. Moreover, we examined the effects on the blood pressure and serum lipids when replacing casein with defatted sardine meal as the protein source.
The results obtained are summarized as follows:
1. With the simultaneous administration of EPA, DHA and Tau for SHR, an improvement in the serum lipids and the inhibitive action of blood pressure elevation were recognized.
2. Compared with the control, a significant inhibitive action on the elevation of ACE activity and the blood pressure were recognized by the simultaneous administration of EPA, DHA, Tau and peptide.
3. When replacing a casein with the defatted serdine meal protein as the protein source, a significant inhibitive action on the elevation was recognized with regard to the serum lipids, but not with regard to ACE activity and the blood pressure compared with the control.
4. By simultaneous administration of these components, the Tau content showed a small increase compared to the control. Also, a large difference was not observed with regard to the fatty acid composition in the brain, but the absolute quantity of DHA increased in the I and IV groups, and a remarkable increase was recognized in the II group compared with the control.
