抄録
The inhibitory effect of Kaempferia parviflora (black ginger) constituents on nitric oxide (NO) production was examined.
From the methanolic extract of K. parviflora rhizome, 16 flavones, 14 flavanones, 2 diarylheptanoids, 2 chalcones and a
stilbene were isolated and their inhibitory activities toward NO production were examined. As a result, two methoxyflavones,
5,7,3’,4’-tetramethylluteolin and 5,7-dimethoxyflavone showed significant activities. Most of the flavanone constituents, except
for 5,7,3’-trimethoxy-4’-hydroxyflavanone, showed lower activities. The most potent active constituent of Black ginger was
the chalcone flavokavin B; its derivative, flavokavin A, also showed significant activity. The curcumin and its derivative,
1-(4-hydroxyphenyl)-7-phenyl-1,6-heptadiene-3,5-dione, showed significant activity. Only one stilbene was isolated, and it showed
low activity.
