抄録
This study aimed to evaluate the anti-inflammatory effects of various strains of Saccharomyces cerevisiae on HaCaT cells. Two
yeast samples, S. cerevisiae CK34, CK78, and two commercial powders (Yeast powder HA, Yeast powder HG), were tested for their
ability to suppress inflammation. No anti-inflammatory activity was observed in Yeast powder HA and HG, while S. cerevisiae CK34
and CK78 exhibited significant effects. All four samples were subsequently subjected to fractionation using a cation-exchange resin,
and the anti-inflammatory properties of each resulting fraction were assessed. Among these, Fraction 5 (Fr.5) from S. cerevisiae
CK78, Yeast powder HA, and Yeast powder HG demonstrated notable anti-inflammatory activity. LC/MS, LC/MS/MS, and heat map
analysis of each yeast’s Fr.5, combined with cell-based assays, identified inosine as one of the bioactive components responsible for
the observed effect in S. cerevisiae CK78.
