Larvae of Pagrus major obtained from artificially cultured parents died with symptoms of swimming disability 7 to 20 days after hatching.Histologically, a large percent of these larvae suffered from occurrence of foreign bodies in a granular or stone form in the urinary bladder and finally from subcutaneous and coelomic hydrops.
Comparing the time course of incidence rates of granular and stone bodies in the urinary bladder and hydrops between larvae from artificially cultured and wild parents led us to a conclusion that hydrops would arise from urinary stones drived from the mineralization of granular bodies initially occurring in the urinary bladder.