A case of multiple primary malignant tumors with squamous cell carcinoma of the mandibular gingiva and adenocarcinoma of the transverse colon which occurred in a 82-year-old female was reported and the Japanese literature from 1975 to 1984 on multiple primary malignant tumors involving the oral region was reviewed.
The results of 72 cases documented statistically were as follows; The average age at first examination which almost consisted with cancer age, was 36.1% in the 7th decade, 25.0% in the 6th decade and 22.2% in the 8th decade individually.
The ratio of male to female was 2.8:1. As for the diagnostic period of first cancer and secondary cancer, the synchronous cancer represented 31.9% and 68.1% in the metachronous cancer. Regard with the pairing of double cancer on oral region and other organs, digestive system such as, stomach, esophagus occupied the largest half of the pairing.
Histologically, squamous cell carcinoma (scc) and carcinoma of the glandular origin or scc in their separate organ showed the highest pairing rate.
