Actinomycosis is commonly associated with cellulitis caused by the other bacterial infections. It is often in remission before confirming the diagnosis owing to the frequent use of antibiotics. In addition, cases presenting with typical symptoms are decreasing. Therefore, confirmed cases of actinomycosis are becoming rare. We report 2 cases of actinomycosis with bone destruction in the oral and maxillofacial region. They were histologically diagnosed on the detection of sulfur granules. One case had bone destruction in the center of the mandible, and the other had bone destruction in the cortex of the mandible. PAPM was effective in both cases.
