G-CSF産生腫瘍と診断した上顎歯肉扁平上皮癌の1例

抄録

A case of gingival squamous cell carcinoma producing G-CSF is reported.A 78-year-old man presented with a granulated mass in the right upper gingiva. Pathological examination of a biopsy specimen revealed a welldifferentiated squamous cell carcinoma. Laboratory ndings on admission showed marked leukocytosis (12.3×10³/μl).
We had planned a partial resection of the maxilla under general anesthesia. However, the operation was canceled on the originally scheduled day, because of fever and leukocytosis (13.6×10³/μl).
After 10 days, tumor resection was performed under general anesthesia, despite fever and leukocytosis (18.3×10³/μl). Postoperatively, the patient's white blood cell count soon decreased, and the fever disappeared.
Immunohistochemically staining with monoclonal anti-G-CSF antibody was positive. The serum G-CSF concentration reached an abnormally high level preoperatively, which soon decreased to the normal range postoperatively.
We diagnosed the disease as gingival squamous cell carcinoma producing G-CSF.