肥満及び肥満傾向の若年男性は，高強度運動後の線溶活性が抑制される

抄録

　[Introduction] High-intensity exercise reportedly promotes fibrinolytic activity. However, fibrinolytic activity may be inhibited in overweight individuals with low-grade inflammation. In this study, using body mass index (BMI) as an indicator of overweight status, we investigated the effects of obesity and pre-obesity on fibrinolytic activity after high-intensity exercise.
　[Materials and Method] The subjects were 12 young men aged 19-23 years. Based on a previous definition of overweight as a BMI of 25 or higher, 7 subjects had a BMI of less than 25 (BMI <25 group) and 5 had a BMI of 25 or higher (BMI ≥25 group). After the subjects had undergone the Cooper test (a 12-minute run), we measured their α2-plasmin inhibitor/plasmin complex (PIC) levels.
　[Results] There was a significant increase in PIC in the BMI <25 group (pre: 0.5 ± 0.02 μg/mL, post: 1.8 ± 0.3 μg/mL, p< 0.01), but no significant difference between the pre- and post-exercise levels was evident in the BMI ≥25 group (pre: 0.5 ± 0.08 μg/mL, post: 0.9 ± 0.1 μg/mL, p> 0.05).
　[Conclusion] Fibrinolytic activity after high-intensity exercise is inhibited in obese and pre-obese young men.