抄録
Hazardous drugs such as anticancer drugs have been detected in the hospital environment and urine of health professionals, and threaten the health of these pharmacy practitioners. These contaminations of the drugs result from the leakage of the drug from the vial at least in part when injections are mixed. In order to decrease the leakage of the drug from the vial, we invented a new rubber stopper for the vials of a hazardous drug, which includes binal bottoms composed of two rubber parts. The result showed that the leakage amount from the vial stoppered with the stopper of binal bottoms was approximately one-seventeenth compared with the amount with a standard single bottom stopper. Since the stopper with binal bottoms includes inner space in itself, a liquid absorber can be stuffed in the space. The leakage amount from the stopper including the liquid absorber was approximately one-fiftieth compared with those from the referenced stopper. Furthermore, the technical improvement which reversed the vial stoppered with the stopper upside down during preparation made the leakage amount undetectable. Since the stopper was composed of separate parts, the outer and inner sides of the stopper can be washed and sterilized before assembly. In addition, the stopper is advantageous for the pharmacy practitioners, since the handling of the vial is almost the same as the one operated conventionally. These results suggest that the stopper is a new candidate item for preventing the exposure and contamination of hazardous drugs.
