2019 年 45 巻 5 号 p. 272-278
Research into the validity of one-dose packaging of hygroscopic medicines is based on the results of non-packaged medicines or medicines stored in packaging containing only one kind of tablet. Although several medicines are clinically prescribed, the stability of several hygroscopic medicines in one-dose packages is unknown. In this study, hygroscopic medicines Glucobay® tablets, Phosblock® tablets, and Magmitt® tablets were packaged using cellophanepolyethylene laminate, and stored at room temperature and under room humidity conditions for 21 days. The medicines were evaluated for their weight change and hardness, along with a visual inspection. Glucobay® tablets were significantly heavier due to moisture absorption, their hardness was reduced, and visual inspection revealed differences. In contrast, the packaging of Glucobay® tablets with Phosblock® tablets or Magmitt® tablets inhibited moisture absorption of Glucobay® tablets, and changes in hardness and visual appearance were suppressed. Packaging of Phosblock® tablets was more effective than packaging of Magmitt® tablets, because Phosblock® tablets are highly absorbent compared with Magmitt® tablets. In addition, the prevention of moisture absorption of Glucobay® tablets was correlated with the number of Phosblock® tablets in one-dose packages. In conclusion, for evaluation of hygroscopic tablets stored in one-dose packages, it is appropriate that analyses are performed using combinations of medicines that are clinically prescribed.
