ノート
ステロイドパルス実施中におけるせん妄発症のリスク因子に関する予備的検討
2020 年 46 巻 8 号 p. 460-465
詳細
2020 年 46 巻 8 号 p. 460-465
Steroid pulse therapy (SPT) refers to the administration of high doses of corticosteroids over a short period of time. SPT is widely used for the management of various diseases. Steroid treatment is associated with a risk of delirium, and reportedly, the risk of psychological symptoms increases with long-term treatment. Few studies have reported SPT-induced delirium. We retrospectively investigated factors associated with SPT-induced delirium.
We investigated 258 patients who received SPT for 3 consecutive days between January 2017 and December 2018. Delirium occurred in 6 (2.3％) patients (all elderly men). Univariate analysis of 79 elderly men showed that liver injury (odds ratio [OR] 9.2, 95％ confidence interval [CI] 1.2 - 69.1), trazodone hydrochloride administration (OR 10.1, 95％ CI 0.7 - 49.6), and cerebrovascular disease (OR 5.7, 95％ CI 0.9 - 112.0) were associated with SPT-induced delirium. The percentage of correct classification with these factors was 93.7％. Preventive strategies are important in patients presenting with the aforementioned risk factors associated with delirium in elderly men.
