抄録
The specially shaped polypropylene bottle has been devised for sterilization of the chlorhexidine gluconate solution by an autoclave. The shape transformation ratio of the bottles and the concentration of the chlorhexidine gluconate solution in the bottles were investigated after autoclaving. The bottles have two characteristic features, concaving on the sides and strengthening of the bottom, which are expected to reduce the transformation during and after sterilization. Bottles were filled with 500ml of the chlorhexidine gluconate solution and sterilized under four conditions, at 100° C for 60 minutes, at 110°C for 40 minutes, at 115°C for 30 minutes and at 120°C for 20 minutes, and the shape transformation ratios were estimated.
These different conditions generated almost the same results of 8.3% expansion of the sides of the bottles. There was no problem with the shape transformation. The remaining ratios of 0.05% and 0.1% of the chlorhexidine gluconate solution in the bottles after sterilization were 100.2%, 99.9% at 100°C for 60 minutes, 99.0%, 99.3% at 110°C for 40 minutes and 95.8%, 98.0% at 115°C for 30 minutes, respectively. These results indicated that there was no decrease of chlorhexidine gluconate by using the bottles. It was suggested that the specially shaped polypropylene bottle was very useful for sterilization of the chlorhexidine gluconate solution by an autoclave.
