抄録
Background: In the 1990s, the longest-lived region of Japan, Okinawa Prefecture, became the 26th place from the top in life expectancy in 2000 with the Okinawa 26 Shock. However, there is an Ogimi village as an area that has maintained longevity. This study is one of the sub-studies in the cohort study of this population. Assuming that there are factors, we are trying to investigate the diet from childhood and extract the characteristics of body usage, habits.
Purpose: To clarify the effect of PGC-1α polymorphism gene on pulse wave velocity, which is an indicator of vascular stiffness.
Subject and method: A person aged 85 or older was walking from his home to a community center in response to a call from the local social welfare council. The study design was a cross-sectional study. During the data acquisition period, PGC-1α polymorphism was examined from oral mucosa samples performed in September 2018. PWV, blood pressure, and pulse were measured as body measurements, body composition, body fat mass/muscle mass ratio, and biological function measurements. I checked the contents of the meal when I was about 10 years old. The analysis was performed using analysis of variance and multiple comparisons using the PGC-1α polymorphism as the explanatory variable and the vascular hardness of the non-dominant foot as the dependent variable. The factor significance was set at p<0.05.
Results: Twenty participants were born before the 1940s and were about 10 years old on a low-carb diet. In them, the PGC-1α polymorphic S/S was found to have an effect of slowing PWV of non-dominant feet compared to G/G ,p<.05. By age group, a significant negative correlation with pulse wave velocity was observed between the ages of 65-69 and 90 years p<.05, and only body fat mass had a significant effect on pulse wave velocity.
Conclusions: PGC-1α polymorphism G/S alone and mixed it in gender factor might soften the vascular stiffness in the brachial-femoral pulse wave velocity of non-dominant foot than G/G in healthy elderly who experienced a low-carbo rough meal in early childhood.
